A brief history of using computers to design biology.
This is a terrific post. Thank you and congratulations on writing it!
My background is chemistry with some math, physics, chemE, and some protein research. I found the piece quite clear, and I loved the demonstration of how ideas from other fields enabled modern genetic design tools.
(I'm sure a sardonic industrial controls engineer I know would be amazed to learn how electrical circuit diagrams are relevant to genetic design)
excellent and very useful post! i have two comments/corrections:
“The Ribosome Binding Site (RBS) Calculator was really the tip of the iceberg.” - the idiom use seems off given the context, since it was the only available tool at the time rather than just one of a much larger number of tools present at the same time.
“In cells, ribosomes are the big proteins that make other proteins.” - ribosomes are ribonucleoprotein complexes, it is misleading to call them proteins. Ribosomal RNAs are doing the heavy lifting functionally.